Drosophila P element transposase induces male recombination additively and without a requirement for P element excision or insertion

Genetics. 1994 Mar;136(3):1013-23. doi: 10.1093/genetics/136.3.1013.

Abstract

P element dysgenesis-associated male recombination in Drosophila was examined with a selective system focused upon a section of the third chromosome divided into eight recombination segments. Tests compared crossing over in the presence of none, one and two doses of P(delta 2-3)(99B), a non-mobile transposase source, in the absence of a mobilizable P element target in the genome. In the presence of the P transposase source, and without a P element target, significant male recombination occurred in genomic regions physically separated from the P(delta 2-3) site. Using two doses of P(delta 2-3) without a P element target, the male recombination rate doubled, and 90% of the crossovers occurred in the pericentric region. The distribution of recombination events, in the absence of P element targets approximates that seen in studies of radiation induced mitotic crossing over and the metaphase chromosome map. Another experiment examined the effects of one dose of P(delta 2-3) on a genome with a single P element target, P(lArB)(87C9), in the third recombination segment. Crossovers increased 58-fold in the immediate region of the P element target.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Crossing Over, Genetic
  • DNA Transposable Elements*
  • Drosophila / enzymology
  • Drosophila / genetics*
  • Female
  • Gene Deletion
  • Gene Rearrangement
  • Genes, Insect
  • Genes, Lethal
  • Genetic Complementation Test
  • Genetic Markers
  • Male
  • Nucleotidyltransferases / genetics*
  • Recombination, Genetic*
  • Transposases

Substances

  • DNA Transposable Elements
  • Genetic Markers
  • Nucleotidyltransferases
  • Transposases