15-Deoxyspergualin controls cyclosporin- and steroid-resistant intestinal acute graft-versus-host disease after allogeneic bone marrow transplantation

M Kasai; T Higa; T Naohara; N Masauzi; M Watanabe; A Matsuura; H Ohizumi; J Tanaka; K Morii; Y Kiyama

15-Deoxyspergualin controls cyclosporin- and steroid-resistant intestinal acute graft-versus-host disease after allogeneic bone marrow transplantation

Bone Marrow Transplant. 1994 Aug;14(2):315-7.

Authors

M Kasai¹, T Higa, T Naohara, N Masauzi, M Watanabe, A Matsuura, H Ohizumi, J Tanaka, K Morii, Y Kiyama, et al.

Affiliation

¹ Sapporo Hokuyu Hospital, Artificial Organ and Transplantation Hospital, Japan.

PMID: 7994248

Abstract

We report a case of cyclosporin- and methylprednisolone-resistant intestinal acute graft-versus-host disease (GVHD) after allogeneic bone marrow transplantation which responded to a new immunosuppressant, 15-deoxyspergualin (DSG). Endoscopy showed lymphoid hyperplasia with CD3+, CD4+, CD8- lymphocyte infiltration into the submucosa of the jejunum and colon. DSG effectively suppressed this intestinal acute GVHD.

Publication types

Case Reports

MeSH terms

Acute Disease
Adrenal Cortex Hormones / therapeutic use
Adult
Bone Marrow Transplantation / immunology*
Cyclosporine / therapeutic use
Drug Resistance
Graft vs Host Disease / drug therapy*
Guanidines / therapeutic use*
Humans
Immunosuppressive Agents / therapeutic use*
Intestinal Diseases / drug therapy*
Male
Transplantation, Homologous

Substances

Adrenal Cortex Hormones
Guanidines
Immunosuppressive Agents
Cyclosporine
gusperimus