Abstract
Several new bioanalogues of (+/-)-N-methyl-N-(1-[3-(4-fluorophenoxy)-2-hydroxy-propyl]piperidin++ +-4-yl) benzothiazol-2-amine (1, sabeluzole, CAS 104383-17-7) were prepared by reacting 1,2-epoxy-3-aryloxypropanes with 4-arylaminopiperidines. Some of these derivatives showed enhanced activity in the potassium cyanide hypoxia test and in the pentetrazol convulsion test in mice compared to 1.
MeSH terms
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Animals
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Anticonvulsants / chemical synthesis*
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Anticonvulsants / pharmacology
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Cell Survival / drug effects
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Cyanides / pharmacology
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Hypoxia / chemically induced
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Hypoxia / drug therapy*
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Male
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Mice
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Mice, Inbred Strains
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Pentylenetetrazole
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Piperidines / chemical synthesis*
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Piperidines / pharmacology
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Seizures / chemically induced
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Seizures / prevention & control
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Thiazoles / pharmacology
Substances
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Anticonvulsants
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Cyanides
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Piperidines
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Thiazoles
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sabeluzole
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Pentylenetetrazole