Relationship between in vitro metabolism of pyrrolizidine alkaloids and extrahepatic toxicity in vivo

Proc West Pharmacol Soc. 1994:37:109-11.
No abstract available

MeSH terms

  • Animals
  • In Vitro Techniques
  • Lethal Dose 50
  • Male
  • Microsomes, Liver / drug effects
  • Microsomes, Liver / metabolism
  • Phenobarbital / pharmacology
  • Plants, Toxic / chemistry
  • Pyrrolizidine Alkaloids / metabolism*
  • Pyrrolizidine Alkaloids / toxicity*
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Pyrrolizidine Alkaloids
  • Phenobarbital