Primary angiomyolipoma of the liver is a rare entity with fewer than 40 cases described in the English literature. Primary hepatic tumors diagnosed during pregnancy are also rare with adenomas, hemangiomas, and hepatocellular carcinoma having been described. This article reports a patient who was diagnosed with a large liver mass at 16 weeks gestation. The patient successfully completed her pregnancy and ultimately underwent resection of a giant hepatic angiomyolipoma. The literature on angiomyolipoma as well as liver tumors during pregnancy is reviewed.