Developmental changes in the effects of metabotropic glutamate receptor antagonists on CA1 long-term potentiation in rat hippocampal slices

Neurosci Lett. 1994 Jul 18;176(1):89-92. doi: 10.1016/0304-3940(94)90878-8.

Abstract

The effects of 100 microM D,L-2-amino-3-phosphonopropionate (AP3), 100 microM D,L-2-amino-4-phosphonobutyric acid (AP4), and 500 microM (R,S)-alpha-methyl-4-carboxyphenylglycine (MCPG), inhibitors of phosphoinositide (PI) turnover mediated by metabotropic glutamate receptors (mGluRs), on the induction of long-term potentiation (LTP) were examined in the CA1 region of hippocampal slices prepared from 15, 30 and 60 day old rats. In 15 or 30 day old rats, AP3 and MCPG applied for 5 min immediately after tetanization inhibited LTP. AP4 was less effective. All inhibitors were ineffective against LTP in 60 day old rats. These data support the hypothesis that the role of metabotropic glutamate receptors in LTP induction is influenced by development.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aging / physiology*
  • Alanine / analogs & derivatives*
  • Alanine / pharmacology
  • Aminobutyrates / pharmacology*
  • Animals
  • Benzoates / pharmacology*
  • Glycine / analogs & derivatives*
  • Glycine / pharmacology
  • Hippocampus / drug effects
  • Hippocampus / growth & development
  • Hippocampus / physiology*
  • In Vitro Techniques
  • Long-Term Potentiation / drug effects*
  • Pyramidal Cells / drug effects
  • Pyramidal Cells / physiology*
  • Rats
  • Receptors, Metabotropic Glutamate / antagonists & inhibitors*

Substances

  • Aminobutyrates
  • Benzoates
  • Receptors, Metabotropic Glutamate
  • 2-amino-3-phosphonopropionic acid
  • alpha-methyl-4-carboxyphenylglycine
  • 2-amino-4-phosphonobutyric acid
  • Alanine
  • Glycine