Synthesis and cytotoxic activity against L1210 leukemia of new aminocyclopenta[c]thiophenones

A Alsaidi; S al Shargapi; P Dallemagne; F Carreiras; P Gauduchon; S Rault; M Robba

doi:10.1248/cpb.42.1605

Synthesis and cytotoxic activity against L1210 leukemia of new aminocyclopenta[c]thiophenones

Chem Pharm Bull (Tokyo). 1994 Aug;42(8):1605-8. doi: 10.1248/cpb.42.1605.

Authors

A Alsaidi¹, S al Shargapi, P Dallemagne, F Carreiras, P Gauduchon, S Rault, M Robba

Affiliation

¹ Centre d'Etudes et de Recherche sur le Médicament de Normandie (Laboratoire de Chimie Thérapeutique) U.F.R. des Sciences Pharmaceutiques, Caen, France.

PMID: 7954912
DOI: 10.1248/cpb.42.1605

Abstract

Synthesis of some new hydroxyaminocyclopenta[c]thiophenones was achieved via halogenation reaction, then formation and finally cleavage of an aziridino ring. The in vitro cytotoxic activity of these compounds was evaluated against L1210 leukemia. The importance of the ketohydroxyethylamino sequence for their activities is discussed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / pharmacology
Antineoplastic Agents / therapeutic use
Cell Count / drug effects
Cell Division / drug effects
Leukemia L1210 / drug therapy*
Magnetic Resonance Spectroscopy
Mice
Stereoisomerism
Thiophenes / chemical synthesis*
Thiophenes / pharmacology
Tumor Cells, Cultured

Substances

Antineoplastic Agents
Thiophenes