Infections remain a major problem for individuals who undergo solid organ transplantation. The risk of these infections is determined by previous or future environmental exposures as well as the patient's immune status. With the use of prophylactic antibiotics, antifungal agents, and the development of selective immunosuppressive agents, the incidence of infection should decrease. Rapid diagnosis and the institution of appropriate therapy are necessary for cure. Further investigation is required to determine the optimal prophylaxis necessary for disease prevention.