Allogeneic marrow transplantation for myelodysplastic syndrome complicating autologous bone marrow transplantation

Cancer Invest. 1994;12(5):484-7. doi: 10.3109/07357909409021407.

Abstract

A patient with refractory relapsed Hodgkin's disease underwent an autologous bone marrow transplant in July 1987 and achieved remission of Hodgkin's disease. He had complete hematological recovery but developed pancytopenia 3 years post bone marrow transplantation with morphological evidence of myelodysplasia. High-dose cyclophosphamide, 200 mg/kg, chemotherapy followed by an allogeneic bone marrow transplant from a HLA-matched sibling was performed in April 1991 with complete hematological recovery. Allogeneic bone marrow transplantation was thus used successfully to treat a potential complication of autologous bone marrow transplantation.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Bone Marrow Transplantation / adverse effects*
  • Cyclophosphamide / therapeutic use
  • Hodgkin Disease / therapy*
  • Humans
  • Male
  • Myelodysplastic Syndromes / therapy*
  • Pancytopenia / etiology
  • Transplantation, Autologous
  • Transplantation, Homologous

Substances

  • Cyclophosphamide