Macromolecular crowding and molecular recognition

J Mol Recognit. 1993 Dec;6(4):211-4. doi: 10.1002/jmr.300060410.

Abstract

The effects of macromolecular crowding upon macromolecular associations in solution, and upon binding of a macromolecular ligand to a surface site, are reviewed. It is demonstrated, by means of two examples, that crowding may lead to significant alterations of biochemical or biological recognition processes at the molecular level.

MeSH terms

  • Binding Sites
  • Binding, Competitive
  • In Vitro Techniques
  • Ligands
  • Macromolecular Substances*
  • Models, Biological
  • Models, Chemical
  • Receptors, Virus / physiology
  • Solutions
  • Thermodynamics

Substances

  • Ligands
  • Macromolecular Substances
  • Receptors, Virus
  • Solutions