Novel isoxazoles which interact with brain cholinergic channel receptors have intrinsic cognitive enhancing and anxiolytic activities

J Med Chem. 1994 Apr 15;37(8):1055-9. doi: 10.1021/jm00034a002.
No abstract available

MeSH terms

  • Alkaloids / metabolism
  • Animals
  • Anti-Anxiety Agents / chemistry
  • Anti-Anxiety Agents / pharmacology*
  • Azocines
  • Binding Sites
  • Brain / drug effects
  • Brain / physiology*
  • Bungarotoxins / metabolism
  • Cognition / drug effects*
  • Isoxazoles / chemistry
  • Isoxazoles / metabolism
  • Isoxazoles / pharmacology*
  • Mice
  • Molecular Structure
  • Motor Activity / drug effects
  • Nicotine / analogs & derivatives
  • Nicotine / chemistry
  • Nicotine / metabolism
  • Quinolizines
  • Rats
  • Receptors, Cholinergic / metabolism*
  • Receptors, Nicotinic / metabolism
  • Stereoisomerism

Substances

  • Alkaloids
  • Anti-Anxiety Agents
  • Azocines
  • Bungarotoxins
  • Isoxazoles
  • Quinolizines
  • Receptors, Cholinergic
  • Receptors, Nicotinic
  • cytisine
  • Nicotine
  • nornicotine