A double-blind trial of captopril or bendrofluazide in newly diagnosed senile hypertension

Curr Med Res Opin. 1994;13(4):214-21. doi: 10.1185/03007999409110486.

Abstract

Hypertension is a major risk factor for stroke and heart disease in the elderly. Eighty-one hypertensive subjects with mild cognitive impairement, aged over 70 years, were drawn from a community screening programme and randomized to either 12.5 mg captopril twice daily or 2.5 mg bendrofluazide daily in a double-blind trial. Subjects were excluded if they had previously received antihypertensive treatment. The mean blood pressure was reduced from 193/101 mmHg to 154/87 mmHg by captopril and from 188/102 mmHg to 151/89 mmHg by bendrofluazide after 24 weeks; there was no significant difference between the two drugs. Seven subjects withdrew due to adverse events. Adverse events occurred more frequently during the 2-week placebo phase than during active treatment with either drug. The only significant detrimental changes in pre-existing conditions were in 3 subjects (2 captopril, 1 bendrofluazide) who were noted to have worsening of their cataracts. One subject on captopril and 4 subjects on bendrofluazide became hypokalaemic. The trial results support the use of captopril as an alternative to bendrofluazide as a first-line antihypertensive agent in the community for elderly people, but large studies are required to measure accurately effects on significant morbidity and mortality.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Bendroflumethiazide / adverse effects
  • Bendroflumethiazide / therapeutic use*
  • Blood Cell Count
  • Blood Pressure / drug effects
  • Captopril / adverse effects
  • Captopril / therapeutic use*
  • Double-Blind Method
  • Female
  • Humans
  • Hypertension / drug therapy*
  • Male
  • Placebos

Substances

  • Placebos
  • Bendroflumethiazide
  • Captopril