Abstract
Eleven patients with disseminated midgut carcinoid tumour disease were subjected to hepatic artery embolisation. In six patients, lymphocytosis with a predominance of NK cells occurred and the cytotoxic activity of isolated lymphocytes increased. A relation between NK cell accumulation and subsequent radiological and biochemical response was observed, and it is suggested that anti-tumour mechanisms other than ischaemia may contribute to the therapeutic response in these patients.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Cytotoxicity, Immunologic
-
Embolization, Therapeutic*
-
Hepatic Artery
-
Humans
-
Intestinal Neoplasms / pathology*
-
Intestinal Neoplasms / therapy*
-
Killer Cells, Natural / cytology*
-
Killer Cells, Natural / immunology*
-
Liver Neoplasms / immunology
-
Liver Neoplasms / secondary*
-
Liver Neoplasms / therapy*
-
Lymphocytes / cytology
-
Lymphocytes / immunology
-
Malignant Carcinoid Syndrome / immunology
-
Malignant Carcinoid Syndrome / pathology*
-
Malignant Carcinoid Syndrome / therapy*
-
Phenotype