Insights into erythroid differentiation obtained from studies on avian erythroblastosis virus

Curr Opin Cell Biol. 1994 Dec;6(6):816-24. doi: 10.1016/0955-0674(94)90050-7.

Abstract

Analysis of the oncogenes v-erbB and v-erbA and their normal proto-oncogene counterparts has revealed several novel aspects of erythroid differentiation. A new erythroid progenitor capable of extended self-renewal has been described, tyrosine kinase receptors and steroid hormone receptors have been found to cooperate in controlling self-renewal, and dramatic alterations in the cell cycle have been found to accompany induction of terminal differentiation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Alpharetrovirus / genetics
  • Alpharetrovirus / physiology*
  • Animals
  • Cell Cycle
  • Cell Transformation, Viral
  • Chickens
  • Erythropoiesis / physiology*
  • Genes, erbA
  • Genes, erbB
  • Receptor Protein-Tyrosine Kinases / physiology
  • Receptors, Estrogen / physiology
  • Transcription, Genetic

Substances

  • Receptors, Estrogen
  • Receptor Protein-Tyrosine Kinases