Rapamycin (Sirolimus) inhibits vascular smooth muscle DNA synthesis in vitro and suppresses narrowing in arterial allografts and in balloon-injured carotid arteries: evidence that rapamycin antagonizes growth factor action on immune and nonimmune cells

Transplant Proc. 1995 Feb;27(1):430-1.
No abstract available

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angioplasty, Balloon / adverse effects
  • Animals
  • Aorta / drug effects
  • Aorta / metabolism
  • Carotid Arteries / drug effects
  • Carotid Arteries / pathology
  • Carotid Arteries / physiology*
  • Cells, Cultured
  • Cyclosporine / pharmacology
  • DNA / biosynthesis*
  • Femoral Artery / drug effects
  • Femoral Artery / physiology*
  • Femoral Artery / transplantation*
  • Immunosuppressive Agents / pharmacology*
  • Male
  • Muscle, Smooth, Vascular / drug effects
  • Muscle, Smooth, Vascular / physiology*
  • Muscle, Smooth, Vascular / transplantation
  • Mycophenolic Acid / pharmacology
  • Polyenes / pharmacology*
  • Rats
  • Rats, Inbred BN
  • Rats, Inbred Lew
  • Rats, Sprague-Dawley
  • Sirolimus

Substances

  • Immunosuppressive Agents
  • Polyenes
  • Cyclosporine
  • DNA
  • Mycophenolic Acid
  • Sirolimus