A high-resolution genetic map of mouse chromosome 5 encompassing the reeler (rl) locus

Genomics. 1994 Oct;23(3):685-90. doi: 10.1006/geno.1994.1557.

Abstract

Using interspecific crosses between BALB/c and Mus spretus (SEG) mice, the murine reeler (rl) gene was mapped to the proximal region of chromosome 5 between the hepatocyte growth factor gene (Hgf) and the D5Mit66 microsatellite. The following order was defined: (centromere)-Cchl2a/Hgf-D5Mit1-D5Nam1/D5-Nam2 -rl/D5Mit61-D5Mit72-Xmv45-Htr5a- Peplb-D5Nam3-D5Mit66. Estimated distances between reeler and the nearest flanking markers D5Nam1 and D5Mit72 are 1.5 and 1.0 cM, respectively (95% confidence level), suggesting that the region could be physically mapped using a manageable number of YAC clones.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Animals
  • Chromosome Mapping*
  • Crosses, Genetic
  • DNA / analysis
  • DNA / genetics
  • DNA, Satellite / genetics
  • Female
  • Genetic Markers
  • Hepatocyte Growth Factor / genetics
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Inbred Strains
  • Mice, Neurologic Mutants / genetics*
  • Muridae
  • Organ Specificity
  • Recombination, Genetic

Substances

  • DNA, Satellite
  • Genetic Markers
  • Hepatocyte Growth Factor
  • DNA