Hypercalcemia caused by PTH-rP associated with lung metastasis from urinary bladder carcinoma: an autopsied case

Intern Med. 1994 Nov;33(11):673-6. doi: 10.2169/internalmedicine.33.673.

Abstract

We analyzed the parathyroid-related protein (PTH-rP) content in tissue specimens obtained from a 61-year-old man with hypercalcemia associated with lung metastasis from urinary bladder carcinoma using radioimmunoassay and immunohistochemistry. Radioimmunoassay showed that the PTH-rP content was higher in metastatic lung tumor tissue than in non-tumorous lung tissue. Immunohistochemical analysis revealed the presence of PTH-rP in tumor cells. Furthermore, proliferation of osteoclasts was found in bone marrow at autopsy. The results suggest that PTH-rP induced humoral hypercalcemia of malignancy in a patient with urinary bladder cancer.

Publication types

  • Case Reports

MeSH terms

  • Bone Marrow / pathology
  • Carcinoma, Transitional Cell / chemistry
  • Carcinoma, Transitional Cell / complications*
  • Carcinoma, Transitional Cell / pathology
  • Carcinoma, Transitional Cell / secondary*
  • Humans
  • Hypercalcemia / etiology*
  • Lung / chemistry
  • Lung / pathology
  • Lung Neoplasms / chemistry
  • Lung Neoplasms / complications*
  • Lung Neoplasms / pathology
  • Lung Neoplasms / secondary*
  • Male
  • Middle Aged
  • Neoplasm Proteins / analysis*
  • Osteoclasts / pathology
  • Parathyroid Hormone-Related Protein
  • Proteins / analysis*
  • Radioimmunoassay
  • Urinary Bladder Neoplasms / pathology*

Substances

  • Neoplasm Proteins
  • PTHLH protein, human
  • Parathyroid Hormone-Related Protein
  • Proteins