Quantitative diagnosis of Schistosoma infections by measurement of circulating antigens in serum and urine

Trop Geogr Med. 1994;46(4 Spec No):233-8.

Abstract

Recent research on the detection of the schistosome circulating antigens, circulating anodic antigen (CAA) and circulating cathodic antigen (CCA), has greatly expanded the scope of applications. In the present paper aspects of assay development, in particular of highly sensitive assays and of field-applicable assays, are discussed. The progress in the use of CAA- and CCA-detection for diagnosis, follow-up of chemotherapy and sero-epidemiological studies is evaluated.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens, Helminth / blood*
  • Antigens, Helminth / urine*
  • Clinical Trials as Topic
  • Enzyme-Linked Immunosorbent Assay
  • Fluoroimmunoassay
  • Follow-Up Studies
  • Glycoproteins / blood*
  • Glycoproteins / urine*
  • Helminth Proteins / blood*
  • Helminth Proteins / urine*
  • Humans
  • Schistosoma / immunology*
  • Schistosomiasis / blood*
  • Schistosomiasis / drug therapy
  • Schistosomiasis / epidemiology
  • Schistosomiasis / immunology
  • Schistosomiasis / urine*
  • Sensitivity and Specificity
  • Seroepidemiologic Studies

Substances

  • Antigens, Helminth
  • CCA protein, Schistosoma mansoni
  • Glycoproteins
  • Helminth Proteins
  • circulating anodic antigen, Schistosoma mansoni