The purpose of this paper is to verify the level of confidence of a new approach to the management of patients with cardiovalvular prosthetic and oral treatment with anticoagulants during high level risk oral surgery procedures. The new protocol includes: interrupted oral anticoagulant treatment; ambulatory regimen instead of hospital regimen; special dentistry management. No hemorrhagic complications occurred in the study sample. This paper concludes with a review of the role of Quick test in the management of patients with cardiac prostheses.