Abstract
We measured cholinergic markers and acetylcholinesterase (AChE) molecular forms after glutamate receptor stimulation of superfused slices of mouse spinal cord at different developmental ages. AChE globular forms were secreted in a dose-dependent fashion. A period of selective sensitivity to excitotoxic agents was detected by increased acetylcholine (ACh) release and AChE secretion (sAChE) at postnatal day 14. Strychnine-resistant glycine stimulation potentiated glutamate-induced AChE release, suggesting N-methyl-D-aspartate (NMDA) receptor involvement.
MeSH terms
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Acetylcholine / metabolism
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Acetylcholinesterase / metabolism
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Animals
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Apoptosis / physiology*
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Biomarkers
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Excitatory Amino Acids / toxicity*
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Glutamic Acid / metabolism
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Mice
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Motor Neurons / enzymology
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Motor Neurons / metabolism*
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Motor Neurons / physiology
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Parasympathetic Nervous System / enzymology
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Parasympathetic Nervous System / metabolism*
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Receptors, Glutamate / drug effects
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Receptors, Glutamate / metabolism
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Receptors, Glutamate / physiology
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Spinal Cord / cytology
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Spinal Cord / enzymology
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Spinal Cord / metabolism
Substances
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Biomarkers
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Excitatory Amino Acids
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Receptors, Glutamate
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Glutamic Acid
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Acetylcholinesterase
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Acetylcholine