Aortic suture line infection caused by Pseudomonas aeruginosa occurred in a 31-year-old man 2 months after orthotopic heart transplantation. Incomplete resection of the mycotic aneurysm and replacement of the ascending aorta with allograft aorta was performed. Subsequently, the infection recurred on the proximal suture line, and reoperation with complete excision of the mycotic aneurysm and allograft replacement of the ascending aorta was performed successfully, without recurrence of the infection.