Goodpasture's syndrome in childhood: treatment with plasmapheresis and immunosuppression

J Clin Apher. 1994;9(2):116-9. doi: 10.1002/jca.2920090204.

Abstract

Goodpasture's syndrome rarely affects children. Therefore, we present our experience in a young boy whose pulmonary hemorrhage was dramatically resolved by three plasma exchanges. We believe the hemorrhage was caused primarily by acute capillaritis. He received cytoxan and steroids and a series of plasma exchanges which removed/suppressed his anti-glomerular basement membrane (anti-GBM) antibody production. However, after a year, his renal function did not return, and he required renal transplantation and continues to do well.

Publication types

  • Case Reports

MeSH terms

  • Anti-Glomerular Basement Membrane Disease / diagnostic imaging
  • Anti-Glomerular Basement Membrane Disease / therapy*
  • Child
  • Combined Modality Therapy
  • Humans
  • Immunosuppressive Agents / therapeutic use*
  • Male
  • Plasma Exchange*
  • Radiography

Substances

  • Immunosuppressive Agents