Four human chromosome 3q and four human chromosome 21 loci map onto sheep chromosome 1q

Mamm Genome. 1995 Mar;6(3):202-5. doi: 10.1007/BF00293014.

Abstract

Eight new loci have been assigned to sheep Chromosome (Chr) 1q by use of a chromosomally characterized minipanel of sheep x hamster cell hybrids. Four loci, which have been mapped to the distal region of human Chr 3q, are ceruloplasmin (CP), sucrase isomaltase (SI), glucose transporter 2 (GLUT2), and ectopic viral integration site 1 (EVI1). The other four loci, on human Chr 21, include interferon alpha receptor (IFNAR); interferon inducible protein p78, murine (MX1); collagen type VI, alpha 1 (COL6A1); and S100 protein, beta polypeptide (S100B). All of these loci, except GLUT2 and MX1, have been mapped onto bovine Chr 1 or are syntenic with loci on this chromosome. The in situ localization of transferrin (TF) to sheep Chr 1q42-q45 confirms our previous assignment of this locus and independently anchors the eight new syntenic loci to sheep Chr 1q.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cattle
  • Chromosome Mapping*
  • Chromosomes, Human, Pair 21*
  • Chromosomes, Human, Pair 3*
  • Cricetinae
  • Humans
  • Hybrid Cells
  • In Situ Hybridization
  • Proteins / genetics
  • Sheep / genetics*
  • Transferrin / genetics

Substances

  • Proteins
  • Transferrin