Abstract
Mycobacterial disease remains a major public health problem and there appears to be a genetic component underlying susceptibility. This paper describes a group of related children who appear to have a genetic predisposition to disseminated atypical mycobacterial infection. Identification of the defect in this group could lead to better understanding of the genetics of susceptibility to mycobacterial infection.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Child, Preschool
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Female
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Humans
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Infant
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Interferon-gamma / pharmacology
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Lipopolysaccharides / pharmacology
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Male
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Monocytes / drug effects
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Monocytes / immunology
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Mycobacterium Infections, Nontuberculous / genetics*
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Mycobacterium Infections, Nontuberculous / immunology*
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Pedigree
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Tumor Necrosis Factor-alpha / biosynthesis
Substances
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Lipopolysaccharides
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Tumor Necrosis Factor-alpha
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Interferon-gamma