Oral candidiasis is the most frequently observed oral mycosis. It can be manifested as a variety of clinical symptoms, and both local and systemic factors may contribute to its development. A confirmation of this infection depends upon the use of appropriate diagnostic tests, in addition to the presence of clinical signs and symptoms. The choice of antifungal agent depends on the location, severity and chronicity of the lesions, as well as the health status of the patient. Oral candidiasis generally responds well to pharmacological treatment. If the infection is persistent or recurrent, a possible underlying homeostatic disturbance should be investigated.