[Changes in the rate of protein biosynthesis in the organs of mice under the action of the delta sleep-inducing peptide and psychoemotional stress]

Izv Akad Nauk Ser Biol. 1995 Mar-Apr:(2):142-8.
[Article in Russian]

Abstract

The effects of delta-sleep-inducing peptide (DSIP) and its analogs (ID-6 and ID-12) on the protein synthesis rate in the mouse brain, liver, and spleen were studied with special reference to mechanisms underlying the adaptogenic action of DSIP. Time-related changes of the protein synthesis rate were estimated in the mouse organs after a single intraperitoneal injection of the peptide (120 mg/kg body weight) and the psycho-emotional stress with or without preliminary (1 h before) injection of the peptide. After DSIP administration, the protein biosynthesis was activated and the dynamics of stress-induced changes of biosynthesis were modified. The data obtained suggest that the mechanisms underlying the DSIP adaptogenic action involve its modulatory effect on the regulatory system of protein biosynthesis.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Animals
  • Brain / drug effects
  • Brain / metabolism
  • Carbon Radioisotopes
  • Delta Sleep-Inducing Peptide / analogs & derivatives
  • Delta Sleep-Inducing Peptide / pharmacology*
  • Liver / drug effects
  • Liver / metabolism
  • Macromolecular Substances
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred Strains
  • Protein Biosynthesis*
  • Proteins / drug effects*
  • Spleen / drug effects
  • Spleen / metabolism
  • Stress, Psychological / metabolism*

Substances

  • Carbon Radioisotopes
  • Macromolecular Substances
  • Proteins
  • Delta Sleep-Inducing Peptide