Do terminal deletions of 11q23 exist? Identification of undetected translocations with fluorescence in situ hybridization

Genes Chromosomes Cancer. 1993 Aug;7(4):204-8. doi: 10.1002/gcc.2870070404.

Abstract

Fluorescence in situ hybridization (FISH) was performed on bone marrow or peripheral blood cells thought to contain a del(11)(q23q25) from four patients who had acute leukemia or myelodysplasia. Cells from all patients were shown to contain translocations that involved chromosome 6 in three of them. Our data suggest that a large proportion of presumptive del(11)(q23) or del(11)(q23q25) chromosomes may represent previously unidentified translocations that can be detected by FISH.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acute Disease
  • Adolescent
  • Adult
  • Aged
  • Child
  • Chromosome Deletion*
  • Chromosomes, Human, Pair 11*
  • Chromosomes, Human, Pair 6*
  • Female
  • Humans
  • In Situ Hybridization, Fluorescence
  • Karyotyping
  • Leukemia / genetics
  • Male
  • Myelodysplastic Syndromes / genetics
  • Translocation, Genetic*