Abstract
These studies defined SRV-2 envelope peptides 96-102, 127-152, and 233-249 as T cell epitopes that induce significant T cell proliferation. Peripheral blood lymphocytes of Celebes macaques (Macaca nigra) exposed to SRV-2 and currently virus- antibody+, cultured with SRV-2 virus show strongly suppressed T cell responses and have two immunoregulatory T cell populations.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Viral / blood
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CD4 Antigens
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CD8 Antigens
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Epitopes
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Immune Tolerance
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In Vitro Techniques
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Lymphocyte Activation
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Macaca / immunology
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Peptide Fragments / immunology
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Retroviruses, Simian / immunology*
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Retroviruses, Simian / isolation & purification
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Simian Acquired Immunodeficiency Syndrome / immunology*
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Simian Acquired Immunodeficiency Syndrome / microbiology
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T-Lymphocyte Subsets / immunology*
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Viral Envelope Proteins / immunology
Substances
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Antibodies, Viral
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CD4 Antigens
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CD8 Antigens
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Epitopes
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Peptide Fragments
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Viral Envelope Proteins