Sequence of an exon of tumour suppressor p53 gene--a comparative study in domestic animals: mutation in a feline solid mammary carcinoma

Br Vet J. 1995 May-Jun;151(3):325-9. doi: 10.1016/s0007-1935(95)80183-9.

Abstract

Partial sequence determinations were performed on exon 8 of tumour suppressor gene p53 of cattle, sheep, goat, horse and pig. High sequence homology between these species and other species including dog, cat, chicken and man is demonstrated. A mutation CGG-->TGG (arginine-->tryptophan) was detected in a feline solid carcinoma of the mammary gland.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Animals, Domestic / genetics*
  • Base Sequence
  • Cat Diseases / genetics*
  • Cat Diseases / pathology
  • Cats
  • DNA Primers / chemistry
  • DNA, Neoplasm / analysis
  • Exons*
  • Genes, p53 / genetics*
  • Humans
  • Mammary Neoplasms, Animal / genetics*
  • Mammary Neoplasms, Animal / pathology
  • Molecular Sequence Data
  • Mutation / genetics*
  • Polymerase Chain Reaction / veterinary
  • Sequence Homology, Nucleic Acid

Substances

  • DNA Primers
  • DNA, Neoplasm