Abstract
The prevalence of alleles of genes of the Plasmodium falciparum population of Asar village in eastern Sudan was monitored over three consecutive years. The characters studied were parasite surface antigens, proteins detected by two-dimensional polyacrylamide gel electrophoresis, enzymes, and drug response. Fluctuations in allele prevalences from one year to another were detected and are discussed in the context of seasonality of malaria transmission in the region studied.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Alleles
-
Aminohydrolases / analysis
-
Aminohydrolases / genetics
-
Animals
-
Antigens, Protozoan / analysis
-
Antigens, Protozoan / genetics
-
Antigens, Surface / analysis
-
Antigens, Surface / genetics
-
Chloroquine / pharmacology
-
Electrophoresis, Gel, Two-Dimensional
-
Endopeptidases / analysis
-
Endopeptidases / genetics
-
Gene Frequency
-
Genes, Protozoan / genetics
-
Genetic Variation
-
Glucose-6-Phosphate Isomerase / analysis
-
Glucose-6-Phosphate Isomerase / genetics
-
Humans
-
Malaria, Falciparum / epidemiology
-
Malaria, Falciparum / parasitology
-
Malaria, Falciparum / transmission*
-
Merozoite Surface Protein 1
-
Plasmodium falciparum / chemistry
-
Plasmodium falciparum / drug effects
-
Plasmodium falciparum / genetics*
-
Prevalence
-
Protein Precursors / analysis
-
Protein Precursors / genetics
-
Protozoan Proteins / analysis
-
Protozoan Proteins / genetics
-
Pyrimethamine / pharmacology
-
Seasons
-
Sudan / epidemiology
Substances
-
Antigens, Protozoan
-
Antigens, Surface
-
Merozoite Surface Protein 1
-
Protein Precursors
-
Protozoan Proteins
-
merozoite surface protein 2, Plasmodium
-
Chloroquine
-
Endopeptidases
-
Aminohydrolases
-
adenine deaminase
-
Glucose-6-Phosphate Isomerase
-
Pyrimethamine