The isolation and structural elucidation of three new neolignans, piperulins [corrected] A, B, and C, as platelet activating factor receptor antagonists from Piper puberulum

J Nat Prod. 1995 Apr;58(4):540-7. doi: 10.1021/np50118a009.

Abstract

Three new neolignans, piperulins [corrected] A [1], B [2], and C [3], were isolated from Piper puberulum. Their structures and relative stereochemistries were determined from spectral data and the X-ray crystallographic analysis of 1. Compounds 1 and 3 inhibit specific platelet activating factor receptor binding with IC50 values of 7.3 and 5.7 microM, respectively.

MeSH terms

  • Animals
  • Blood Platelets / drug effects
  • Blood Platelets / metabolism
  • Bridged Bicyclo Compounds / isolation & purification*
  • Bridged Bicyclo Compounds / pharmacology
  • China
  • Crystallography, X-Ray
  • In Vitro Techniques
  • Lignans / isolation & purification*
  • Lignans / pharmacology
  • Magnetic Resonance Spectroscopy
  • Plants, Medicinal / chemistry*
  • Platelet Membrane Glycoproteins / antagonists & inhibitors*
  • Rabbits
  • Receptors, Cell Surface*
  • Receptors, G-Protein-Coupled*
  • Spectrophotometry, Ultraviolet

Substances

  • Bridged Bicyclo Compounds
  • Lignans
  • Platelet Membrane Glycoproteins
  • Receptors, Cell Surface
  • Receptors, G-Protein-Coupled
  • piperulin A
  • piperulin B
  • piperulin C
  • platelet activating factor receptor