Lack of genetically determined structural variants of the human serotonin-1E (5-HT1E) receptor protein points to its evolutionary conservation

D Shimron-Abarbanell; M M Nöthen; J Erdmann; P Propping

doi:10.1016/0169-328x(95)00003-b

Lack of genetically determined structural variants of the human serotonin-1E (5-HT1E) receptor protein points to its evolutionary conservation

Brain Res Mol Brain Res. 1995 Apr;29(2):387-90. doi: 10.1016/0169-328x(95)00003-b.

Authors

D Shimron-Abarbanell¹, M M Nöthen, J Erdmann, P Propping

Affiliation

¹ Institute of Human Genetics, University of Bonn, Germany.

PMID: 7609628
DOI: 10.1016/0169-328x(95)00003-b

Abstract

Using single strand conformational analysis, we screened the complete coding sequence of the serotonin-1E (5-HT1E) receptor gene for the presence of DNA sequence variation in a sample of 157 unrelated individuals. We detected only a silent C-->T transition at the third position of codon 177. The lack of significant mutations leading to structural variants of the human 5-HT1E receptor protein points to a high evolutionary conservation of this receptor protein.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Sequence
Biological Evolution*
Case-Control Studies
Humans
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational*
Receptors, Serotonin / genetics*

Substances

Receptors, Serotonin