Further evidence supporting the importance of and the restrictions on a carbon-centered radical for high antimalarial activity of 1,2,4-trioxanes like artemisinin

J Med Chem. 1995 Jun 23;38(13):2273-5. doi: 10.1021/jm00013a001.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antimalarials / chemistry*
  • Antimalarials / pharmacology
  • Artemisinins*
  • Carbon / chemistry
  • Heterocyclic Compounds / chemistry*
  • Heterocyclic Compounds / pharmacology
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / pharmacology
  • Structure-Activity Relationship

Substances

  • Antimalarials
  • Artemisinins
  • Heterocyclic Compounds
  • Sesquiterpenes
  • Carbon
  • artemisinin