Pathway of promoter melting by Bacillus subtilis RNA polymerase at a stable RNA promoter: effects of temperature, delta protein, and sigma factor mutations

Biochemistry. 1995 Jul 4;34(26):8465-73. doi: 10.1021/bi00026a030.

Abstract

Bacillus subtilis RNA polymerase (RNAP) contains a catalytic core (beta beta' alpha 2; or E) associated with one of several sigma factors, which determine promoter recognition, and delta protein, which enhances promoter selectivity. We have shown previously that specific mutations in sigma A region 2.3, or addition of delta, decrease the ability of RNAP to melt the ilv-leu promoter. Here we extend these studies to a stable RNA promoter, PtmS, which controls transcription of seven tRNA genes. KMnO4 footprinting was used to visualize DNA melting at PtmS as a function of both temperature and the protein composition of the RNAP holoenzyme. We propose that the pathway leading to productive initiation includes several intermediates: a closed complex (RPc), a complex in which DNA melting has nucleated within the conserved TATA element (RPn), and an open complex in which DNA-melting extends to at least -4 (RPo1). RNAP reconstituted with either of two mutant sigma A proteins, Y189A and W192A, was defective for both the nucleation and propagation of the transcription bubble while a third sigma A mutant, W193A, allows normal nucleation of DNA-melting, but does not efficiently propagate the melted region downstream.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Bacillus subtilis / enzymology*
  • Bacillus subtilis / genetics*
  • Base Sequence
  • Conserved Sequence
  • DNA, Bacterial / chemistry*
  • DNA, Bacterial / metabolism*
  • DNA-Directed RNA Polymerases / biosynthesis
  • DNA-Directed RNA Polymerases / isolation & purification
  • DNA-Directed RNA Polymerases / metabolism*
  • Deoxyribonuclease I
  • Kinetics
  • Molecular Sequence Data
  • Nucleic Acid Denaturation
  • Operon*
  • Point Mutation
  • Promoter Regions, Genetic*
  • RNA-Binding Proteins / biosynthesis
  • RNA-Binding Proteins / isolation & purification
  • RNA-Binding Proteins / metabolism*
  • Recombinant Proteins / biosynthesis
  • Recombinant Proteins / isolation & purification
  • Recombinant Proteins / metabolism
  • Restriction Mapping
  • Sigma Factor / biosynthesis
  • Sigma Factor / isolation & purification
  • Sigma Factor / metabolism*
  • TATA Box
  • Thermodynamics
  • Transcription, Genetic

Substances

  • DNA, Bacterial
  • RNA-Binding Proteins
  • Recombinant Proteins
  • Sigma Factor
  • DNA-Directed RNA Polymerases
  • Deoxyribonuclease I