This study examined demographic, behavioral, and attitudinal variables and drug use in adolescents with physical disabilities as measured by the Primary Prevention Awareness, Attitude and Usage Scales (PPAAUS). When compared to the same age students in the general population, the students with physical disabilities responded differently. A chi-square analysis was performed between drug use and demographic, behavioral, and attitudinal variables. Results found for physically disabled students drug use correlated at p < .05 with feelings toward school, negative disruptive behaviors, reported activities attended, and reported grade average.