Abstract
Amyloidosis and prionosis are disorders of protein conformation. The general mechanisms involved in amyloidogenesis are reviewed here. Recent progress in the molecular pathogenesis of cerebral amyloids is illustrated by three genetic disorders: hereditary amyloid angiopathies of Icelandic and Dutch origins and Gerstmann-Sträussler-Scheinker disease.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
-
Review
MeSH terms
-
Aged
-
Alzheimer Disease / diagnosis*
-
Alzheimer Disease / genetics
-
Amyloid beta-Protein Precursor / genetics
-
Amyloidosis / diagnosis*
-
Amyloidosis / genetics
-
Apolipoproteins E / genetics
-
Brain / pathology
-
Brain Diseases / diagnosis*
-
Brain Diseases / genetics
-
Cerebral Amyloid Angiopathy / diagnosis
-
Cerebral Amyloid Angiopathy / genetics
-
Cerebral Hemorrhage / diagnosis
-
Cerebral Hemorrhage / genetics
-
Dementia / diagnosis*
-
Dementia / genetics
-
Gerstmann-Straussler-Scheinker Disease / diagnosis
-
Gerstmann-Straussler-Scheinker Disease / genetics
-
Humans
-
Microscopy, Electron
-
Neurofibrils / pathology
-
Prions / genetics
Substances
-
Amyloid beta-Protein Precursor
-
Apolipoproteins E
-
Prions