Developmental abnormalities and cortical sulcal enlargement in psychosis

Schizophr Res. 1995 Aug 1;16(2):121-5. doi: 10.1016/0920-9964(94)00070-o.

Abstract

Neurodevelopmental abnormalities and cortical sulcal enlargement both occur in schizophrenia. To test the hypothesis that these abnormalities were related, CT scans from 164 psychotic patients (80 with schizophrenia) were reviewed. Neurodevelopmental abnormalities were observed in 11%. Abnormalities were equally prevalent in schizophrenia and other psychotic disorders. Cortical sulcal enlargement was observed in 39% of patients with schizophrenia, and was not associated with developmental abnormalities. Different mechanisms may contribute to distinct structural abnormalities.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Bipolar Disorder / diagnostic imaging
  • Bipolar Disorder / psychology
  • Brain Damage, Chronic / diagnostic imaging*
  • Brain Damage, Chronic / psychology
  • Cerebral Cortex / abnormalities*
  • Cerebral Cortex / diagnostic imaging
  • Depressive Disorder / diagnostic imaging
  • Depressive Disorder / psychology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neurocognitive Disorders / diagnostic imaging*
  • Neurocognitive Disorders / psychology
  • Psychotic Disorders / diagnostic imaging
  • Psychotic Disorders / psychology
  • Risk Factors
  • Schizophrenia / diagnostic imaging*
  • Schizophrenic Psychology*
  • Tomography, X-Ray Computed*