Kimura's disease is an uncommon chronic inflammatory process of obscure origin. It is more common among Orientals and affects particularly the young male. Sites of predilection include the head and neck region, primarily the subcutaneous tissue and dermis. Unusual sites of occurrence that have been reported include the kidney, the orbit, the ear and the spermatic cord. Kimura's disease involving a major nerve bundle has not been described, and we report here the findings of a case of histologically proven Kimura's disease of the median nerve occurring in a 21-year-old Chinese girl. Typical diagnostic histological features of Kimura's disease in contrast to angiolymphoid hyperplasia, and the treatment options for Kimura's disease are also described.