A new paclitaxel photoaffinity analog with a 3-(4-benzoylphenyl)propanoyl probe for characterization of drug-binding sites on tubulin and P-glycoprotein

J Med Chem. 1995 Sep 29;38(20):3891-4. doi: 10.1021/jm00020a001.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism*
  • Affinity Labels / metabolism*
  • Animals
  • Antineoplastic Agents / metabolism*
  • Binding Sites
  • Mice
  • Paclitaxel / analogs & derivatives*
  • Paclitaxel / metabolism*
  • Taxoids*
  • Tubulin / metabolism*

Substances

  • 3'-N-(4-benzoyldihydrocinnamoyl)-3'-N-debenzoylpaclitaxel
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Affinity Labels
  • Antineoplastic Agents
  • Taxoids
  • Tubulin
  • Paclitaxel