The CHIP28 water channel visualized in ice by electron crystallography

Nat Struct Biol. 1995 Sep;2(9):726-9. doi: 10.1038/nsb0995-726.

Abstract

Electron crystallography of frozen-hydrated two-dimensional crystals of deglycosylated human erythrocyte CHIP28 reveals an aqueous vestibule in each monomer leading to the water-selective channel that is enclosed by multiple transmembrane alpha-helices.

Publication types

  • Letter

MeSH terms

  • Cell Membrane Permeability
  • Crystallography / methods*
  • Electrons
  • Erythrocytes / chemistry
  • Erythrocytes / metabolism
  • Freezing
  • Glycosylation
  • Humans
  • Ion Channels / chemistry*
  • Ion Channels / metabolism
  • Protein Structure, Secondary
  • Water / metabolism*

Substances

  • Ion Channels
  • Water