A role for CD5 in TCR-mediated signal transduction and thymocyte selection

Science. 1995 Jul 28;269(5223):535-7. doi: 10.1126/science.7542801.

Abstract

CD5 is a transmembrane protein that is expressed on the surface of T cells and a subset of B cells. The absence of CD5 rendered thymocytes hyperresponsive to stimulation through the T cell antigen receptor (TCR) in vitro. Selection of T cells expressing three distinct transgenic TCRs was also abnormal in CD5-deficient mice. These observations indicate that CD5 can influence the fate of developing thymocytes by acting as a negative regulator of TCR-mediated signal transduction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, CD / immunology*
  • CD3 Complex / metabolism
  • CD5 Antigens
  • Female
  • Lymphocyte Activation*
  • Male
  • Mice
  • Mice, Transgenic
  • Phosphorylation
  • Protein-Tyrosine Kinases / metabolism
  • Receptors, Antigen, T-Cell / immunology*
  • Signal Transduction*
  • T-Lymphocyte Subsets / immunology
  • T-Lymphocytes / immunology*
  • Thymus Gland / immunology
  • ZAP-70 Protein-Tyrosine Kinase

Substances

  • Antigens, CD
  • CD3 Complex
  • CD5 Antigens
  • Receptors, Antigen, T-Cell
  • Protein-Tyrosine Kinases
  • ZAP-70 Protein-Tyrosine Kinase
  • Zap70 protein, mouse