CD44 is expressed throughout pre-implantation human embryo development

Hum Reprod. 1995 Feb;10(2):425-30. doi: 10.1093/oxfordjournals.humrep.a135955.

Abstract

The cell surface glycoprotein CD44 has been demonstrated in a variety of cell types in embryonic and adult tissues. We have established that CD44 is present on human oocytes, cumulus cells, early embryos and pre-hatched blastocysts by indirect immunofluorescence. We have also shown that CD44 is present on 8-11 week placental stroma cells, but not on the trophoblast. These findings demonstrate that CD44 is present throughout preimplantation development, and that down-regulation occurs on the embryonic surface after implantation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blastocyst / metabolism*
  • Blastocyst / physiology
  • Carrier Proteins / metabolism*
  • Embryonic and Fetal Development*
  • Female
  • Fluorescent Antibody Technique
  • Humans
  • Hyaluronan Receptors
  • Integrins / metabolism
  • Placenta / cytology
  • Placenta / metabolism
  • Pregnancy
  • Pregnancy Trimester, First
  • Receptors, Cell Surface / metabolism*
  • Receptors, Lymphocyte Homing / metabolism*
  • Staining and Labeling
  • Stromal Cells / metabolism
  • Trophoblasts / metabolism

Substances

  • Carrier Proteins
  • Hyaluronan Receptors
  • Integrins
  • Receptors, Cell Surface
  • Receptors, Lymphocyte Homing