Localization of murine macrophage inducible nitric oxide synthase to mouse chromosome 11

Genomics. 1994 Aug;22(3):646-7. doi: 10.1006/geno.1994.1441.

Abstract

There are at least three distinct nitric oxide (NO) synthase genes. Brain and endothelial NO synthases are constitutively synthesized, while NO synthase is inducible by cytokines in macrophages. We have utilized a backcross of (C57BL/6J x Mus spretus) x C57BL/6J to map the inducible NO synthase (Nos2). We report the chromosomal mapping of Nos2 to mouse chromosome 11, 3.3 cM proximal to Scya2.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Oxidoreductases / genetics*
  • Animals
  • Chromosome Mapping*
  • Crosses, Genetic
  • Female
  • Genetic Markers
  • Macrophages / enzymology*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Muridae
  • Nitric Oxide Synthase

Substances

  • Genetic Markers
  • Nitric Oxide Synthase
  • Amino Acid Oxidoreductases