Dideoxy sequencing and structural analysis of the rat insulin-like growth factor binding protein-1 gene

Biochim Biophys Acta. 1994 May 17;1218(1):95-8. doi: 10.1016/0167-4781(94)90106-6.

Abstract

Insulin-like growth factor binding protein-1 (IGFBP-1) is an important modulator of IGF bioavailability. To facilitate studies of IGFBP-1 regulation and function in rodent models, we cloned the rat IGFBP-1 gene and analyzed its structure by dideoxy sequencing. The rat IGFBP-1 gene is relatively small (approximately 5 kb) and contains 4 exons and 3 introns, similar to the human IGFBP-1 gene.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Carrier Proteins / genetics*
  • Cloning, Molecular
  • DNA, Complementary
  • Humans
  • Insulin-Like Growth Factor Binding Protein 1
  • Insulin-Like Growth Factor I*
  • Molecular Sequence Data
  • Rats

Substances

  • Carrier Proteins
  • DNA, Complementary
  • Insulin-Like Growth Factor Binding Protein 1
  • Insulin-Like Growth Factor I

Associated data

  • GENBANK/L22979