Altered angiotensin-II receptors in human hepatocellular and hepatic metastatic colon cancers

Ann Surg. 1994 May;219(5):500-6; discussion 506-7. doi: 10.1097/00000658-199405000-00008.

Abstract

Objective: To characterize angiotensin-II receptor density and affinity in normal and cirrhotic livers and in hepatocellular and metastatic colorectal cancer.

Summary background data: Several studies have indicated a possible beneficial effect of angiotensin-II as a biologic response modifier in the treatment of hepatic or metastatic colon cancer. This is based on evidence that angiotensin-II will cause a selective increase in arterial vasoconstriction in normal liver compared with tumor.

Methods: Human hepatoma (5), metastatic colon (10), or cirrhotic (3) liver was obtained. Non-tumor-bearing regions served as normal liver. Angiotensin-II receptor binding was determined on membranes with 125I-angiotensin-II and in situ studies were performed using the biotin-avidin detection system.

Results: Angiotensin-II receptor density was markedly down-regulated in tumor compared with normal or cirrhotic liver.

Conclusions: A loss of angiotensin-II receptors occurs on the neovasculature of hepatic tumors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Animals
  • Carcinoma, Hepatocellular / blood supply
  • Carcinoma, Hepatocellular / metabolism*
  • Carcinoma, Hepatocellular / secondary*
  • Colorectal Neoplasms / metabolism*
  • Colorectal Neoplasms / secondary*
  • Female
  • Humans
  • In Vitro Techniques
  • Liver / metabolism
  • Liver Cirrhosis / metabolism
  • Liver Neoplasms / blood supply
  • Liver Neoplasms / metabolism*
  • Liver Neoplasms / secondary*
  • Liver Neoplasms, Experimental / blood supply
  • Liver Neoplasms, Experimental / metabolism
  • Male
  • Middle Aged
  • Neovascularization, Pathologic / metabolism
  • Rats
  • Receptors, Angiotensin / metabolism*

Substances

  • Receptors, Angiotensin