Abstract
Analyses of the ionic pore of ligand-gated ion channels at the amino acid level reveal a structural and functional stratification of the M2 channel domain. Mutations in the equatorial and outer regions affect channel gating, whereas mutations of other amino acid rings alter ionic permeability or selectivity.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Binding Sites
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Ion Channel Gating / physiology
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Ion Channels / antagonists & inhibitors
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Ion Channels / chemistry*
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Protein Structure, Tertiary*
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Receptors, Neurotransmitter / chemistry*
Substances
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Ion Channels
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Receptors, Neurotransmitter