Abstract
Neurotrophins such as NT-3 are subject to complex regulation during epileptic seizures. Pilocarpine at a dose of 250 mg/kg induced either limbic seizures (LS) or limbic motor status epilepticus (LMSE) in adult rats. In situ hybridization signals for NT-3 mRNA declined moderately after LS and were nearly lost in LMSE at 3-4 h. Loss of NT-3 mRNA expression does not correlate with cell death and may reflect a functional down-regulation in certain hippocampal neurons.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Disease Models, Animal
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Epilepsy / chemically induced
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Epilepsy / metabolism
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Hippocampus / metabolism*
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In Situ Hybridization
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Male
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Nerve Growth Factors / biosynthesis*
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Neurotrophin 3
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Pilocarpine* / pharmacology
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RNA, Messenger / metabolism*
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Rats
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Rats, Sprague-Dawley
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Seizures / chemically induced*
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Seizures / metabolism
Substances
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Nerve Growth Factors
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Neurotrophin 3
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RNA, Messenger
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Pilocarpine