Abnormalities of chromosome 5q correlate with morphologic features of better prognosis in clear cell renal carcinomas

J Podolski; T Huzarski; T Byrski; A Tołoczko; S Wrzecion; A Sikorski; P Mahoy; K Huebner; P Rabbitts; J Lubiński

Abnormalities of chromosome 5q correlate with morphologic features of better prognosis in clear cell renal carcinomas

Pol J Pathol. 1995;46(3):163-6.

Authors

J Podolski¹, T Huzarski, T Byrski, A Tołoczko, S Wrzecion, A Sikorski, P Mahoy, K Huebner, P Rabbitts, J Lubiński

Affiliation

¹ Department of Genetics and Pathology, Medical Academy, Szczecin.

PMID: 7496735

Abstract

Aberrations of the long arm of chromosome 5 (5q) were studied in 79 clear cell renal carcinomas (clear cell RCC) by LOH (loss of heterozygosity) method, using microsatellite markers D5S107, CRTL1, LNS-CA, IL-9.RP1, CFS1R and GeneScan analysis software. Alterations of chromosome 5q were detected in 42% of cases. We found, that accumulation of genomic abnormalities at multiple loci of 5q, especially in 5q21-qter region, where genes for cytokines are located, correlates with morphologic features of better prognosis.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Adenocarcinoma, Clear Cell / genetics*
Adenocarcinoma, Clear Cell / pathology
Base Sequence
Chromosome Aberrations / genetics*
Chromosomes, Human, Pair 5 / genetics*
Cytokines / genetics
DNA, Neoplasm / analysis
Genetic Markers
Humans
Kidney Neoplasms / genetics*
Kidney Neoplasms / pathology
Molecular Sequence Data
Polymerase Chain Reaction
Prognosis

Substances

Cytokines
DNA, Neoplasm
Genetic Markers