Abstract
Clonal disorders of large granular lymphocytes (LGL) of either CD3- (NK cell) or CD 3+ (T-cell) phenotype have been described. B-cell malignancies such as hairy cell leukemia and non-Hodgkin's lymphoma have been observed in association with the T-cell type of LGL leukemia. Here we report the occurrence of LGL lymphocytosis in four patients with Hodgkin's disease. Immunophenotyping studies showed that these LGL were CD 3- in three patients and CD3+ in the other. LGL were polyclonally expanded in both patients in whom clonality could be assessed.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Bleomycin / administration & dosage
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CD3 Complex / analysis
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Dacarbazine / administration & dosage
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Doxorubicin / administration & dosage
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Etoposide / administration & dosage
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Hodgkin Disease / blood*
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Hodgkin Disease / drug therapy
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Hodgkin Disease / pathology
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Humans
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Killer Cells, Natural / pathology
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Lymphocytes / pathology*
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Lymphocytosis / blood*
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Mechlorethamine / administration & dosage
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Neoplasm Staging
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Prednisone / administration & dosage
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Procarbazine / administration & dosage
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T-Lymphocytes / pathology
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Vinblastine
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Vincristine / administration & dosage
Substances
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CD3 Complex
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Bleomycin
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Procarbazine
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Mechlorethamine
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Vincristine
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Vinblastine
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Etoposide
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Dacarbazine
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Doxorubicin
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Prednisone
Supplementary concepts
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ABVD protocol
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MOPP protocol
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VAV protocol