Atrial fibrillation is one of the most common symptomatic sustained arrhythmias seen in clinical practice. Long-term control of heart rate and maintenance of sinus rhythm often require chronic antiarrhythmic therapy. For patients with disabling symptoms of atrial fibrillation that cannot be controlled with pharmacologic therapy, catheter ablation techniques of the atrioventricular junction and surgical procedures aimed at maintaining sinus rhythm have now been effectively used. The efficacy, risks and limitations of pharmacologic and non-pharmacologic therapies are presented in this review article.